Event that produces behavioral responses over a wide area. Fourth, behavioral responses to an emergency event could include dramatic increases but also dramatic decreases in call frequency or mobility behavior. Broad assumptions, backed up by some evidence in the literature [15, 19], suggest that people will call more and become more mobile during and after emergency events. The logic underlying this belief is that people will call others to tell them about the event and will move away from any danger. This might be true for some cases and on some time scales. An alternate possibility is that initial evacuation or escape from a dangerous situation, such as a tsunami, could preclude the ability to make a phone call. In this case, we would find WP1066 solubility increased mobility but decreased call frequency. Another possibility is a situation where an emergency event, such as a flash flood destroys roads or other transportation infrastructure, forcing people to stay in place and disrupting other daily routines. In this second case, we might find decreased mobility but increased call frequency. Thus, there are strong theoretical reasons to expect dramatic decreases in certain behaviors in the immediate aftermath of some emergency events. An effective event detection system must identify both increases and decreases in both call and movement frequency.Identifying behavioral anomaliesOur proposed approach for detecting abnormal communication patterns is designed to capture not only days and regions with higher than usual call frequency, movement frequency, or both, but also days and regions with lower than usual levels of these behaviors. The assessment is performed longitudinally at the site level in the first step of our system. At the second step, the disruptions from the first step are combined across sites for each day, allowing us to determine the spatial extent of behavioral anomalies and if there was more than one possible event on the same day. Step 1: Identifying days with order RO5186582 anomalous human behavior at one site. In order to separate anomalous from routine behaviors (both pre-event routine or post-event routine behaviors), we create reference periods of time. We divide the set of days with cellular communication data from a site into subsets of T consecutive days. The length T of the reference time periods is important and must be selected based on two considerations: (i) T should be sufficiently small such that fluctuations in the number of active towers and the number of callers in each site during T consecutive days are not excessive; and (ii) T should be sufficiently large such that the effects of emergency events and the post-event disaster period are reasonably low with respect to periods of T consecutive days. After a close examination of the temporal dynamics ofPLOS ONE | DOI:10.1371/journal.pone.0120449 March 25,9 /Spatiotemporal Detection of Unusual Human Population Behaviorthe cellular network of the provider of the Rwandan CDRs and of the types of events that we know to have occurred between June 1, 2005 and January 1, 2009, we decided to use T = 60. We consider each period P of T consecutive days with available CDRs from a site S. For each day t in P, we look at the spatiotemporal trajectories of callers who made at least one call from S. We use Poisson models to estimate: (1) the probability that a random caller on day t made more calls than a random caller on a random day in P other than t; and (2) the probability that a random caller.Event that produces behavioral responses over a wide area. Fourth, behavioral responses to an emergency event could include dramatic increases but also dramatic decreases in call frequency or mobility behavior. Broad assumptions, backed up by some evidence in the literature [15, 19], suggest that people will call more and become more mobile during and after emergency events. The logic underlying this belief is that people will call others to tell them about the event and will move away from any danger. This might be true for some cases and on some time scales. An alternate possibility is that initial evacuation or escape from a dangerous situation, such as a tsunami, could preclude the ability to make a phone call. In this case, we would find increased mobility but decreased call frequency. Another possibility is a situation where an emergency event, such as a flash flood destroys roads or other transportation infrastructure, forcing people to stay in place and disrupting other daily routines. In this second case, we might find decreased mobility but increased call frequency. Thus, there are strong theoretical reasons to expect dramatic decreases in certain behaviors in the immediate aftermath of some emergency events. An effective event detection system must identify both increases and decreases in both call and movement frequency.Identifying behavioral anomaliesOur proposed approach for detecting abnormal communication patterns is designed to capture not only days and regions with higher than usual call frequency, movement frequency, or both, but also days and regions with lower than usual levels of these behaviors. The assessment is performed longitudinally at the site level in the first step of our system. At the second step, the disruptions from the first step are combined across sites for each day, allowing us to determine the spatial extent of behavioral anomalies and if there was more than one possible event on the same day. Step 1: Identifying days with anomalous human behavior at one site. In order to separate anomalous from routine behaviors (both pre-event routine or post-event routine behaviors), we create reference periods of time. We divide the set of days with cellular communication data from a site into subsets of T consecutive days. The length T of the reference time periods is important and must be selected based on two considerations: (i) T should be sufficiently small such that fluctuations in the number of active towers and the number of callers in each site during T consecutive days are not excessive; and (ii) T should be sufficiently large such that the effects of emergency events and the post-event disaster period are reasonably low with respect to periods of T consecutive days. After a close examination of the temporal dynamics ofPLOS ONE | DOI:10.1371/journal.pone.0120449 March 25,9 /Spatiotemporal Detection of Unusual Human Population Behaviorthe cellular network of the provider of the Rwandan CDRs and of the types of events that we know to have occurred between June 1, 2005 and January 1, 2009, we decided to use T = 60. We consider each period P of T consecutive days with available CDRs from a site S. For each day t in P, we look at the spatiotemporal trajectories of callers who made at least one call from S. We use Poisson models to estimate: (1) the probability that a random caller on day t made more calls than a random caller on a random day in P other than t; and (2) the probability that a random caller.