Herapy is important in the management of those patients. There are few data about septic shock etiology in kidney transplant recipients. Objectives: The aim of this study is PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/20725854 to ascertain by far the most popular septic shock etiologic agents in kidney transplant recipients. Setting: A kidney transplant specialized ICU within a 90-bed public hospital. Solutions: We prospectively followed (from Could 2000 to December 2001) kidney transplant recipients admitted to ICU with diagnosis of septic shock in accordance with SCCM/ACCP criteria. ICU resource utilization, microbiological identification and 28-day mortality had been recorded. Apache II score for each patient was calculated within 24 hours of admission. Outcomes: We studied 14 (ten M/4 F) consecutive sufferers admitted to ICU with septic shock diagnosis. The imply age was 43 ?9.five years and mean Apache II was 23.7 ?7.three. All individuals were receiv-Available on the net http://ccforum.com/supplements/6/Sing immunosuppression therapy at ICU admission and 11 (78,five ) were inside the 1st year of transplantation. The sources of infection were: lungs (n = six), intra-abdominal (n = four), endocarditis (n = two), central venous catheter (n = 1) and central nervous MedChemExpress YL0919 method (n = 1). Essentially the most popular isolated microorganisms were: Candida (n = 5), cytomegalovirus (n = four), Staphylococcus aureus (n = 3), Acinetobacter baumanii (n = two), Escherichia coli (n = 2), Pneumocystis carinii (n = two), Klebsiella (n = 1) and Mycobacterium tuberculosis (n = 1). In only three (21 ) sufferers just one particular agent was isolated and in a different three (21 ) sufferers we were not capable to identify the etiologic agent. The mean length of ICU stay was 15 ?15.days and of mechanical ventilation was 12.5 ?16 days. In ten (71 ) of these patients a pulmonary artery catheter was inserted and there was require for renal replacement therapy in 13 (93 ) individuals. The 28-day mortality was 71 and all round ICU mortality was 78.five .Conclusions: Even though kidney transplant recipients are susceptible to opportunistic infections because of immunosuppressive therapy, bacteria stay a frequent septic shock etiologic agent in these patients.PColistin within the therapy of infections from multiresistant Gram (? bacilliN Markou*, P Malamos*, D Hroni*, I Alamanos*, A Damianos, H Apostolakos* *ICU-B, KAT Hospital, Athens, Greece; Department of Pulmonary Medicine, Hospital `A Fleming’, Athens, Greece Objective: To present our practical experience with i.v. colistin inside the remedy of infections with multiresistant Gram (? bacilli. Components and solutions: Fourteen sufferers aged 20?1 years old, with extreme infection from multiresistant Gram (? bacilli, sensitive only to colistin. Of your patients, 11 have been critically ill and mechanically ventilated, with an APACHE II score eight?2, plus the other 3 have been non-intubated patients with acute respiratory failure, treated inside the ward. All individuals received intravenous colistin (150,000 U/kg i.v., adjusted for creatinine clearance). A second antibiotic (in 11 instances high-dose b-lactam in continuous intravenous infusion) was added in the regimen. In total 16 courses of i.v. colistin have been given, for the following infections: ventilator-associated pneumonia (VAP) (nine cases), nosocomial pneumonia in non-intubated sufferers (three), sepsis of unknown main origin (one particular), urosepsis (one particular), catheter-related sepsis (two). In all circumstances, in spite of documented resistance, was incorporated in the therapeutic regimen. The bacteria responsible had been P. Aeruginosa (14 cases) or Acinetobacter baumanii (two.