Diffusion of precise suggestions, addressing each of the aspects from the use of LAI antipsychotics, will improve clinicians’ perceived competence. It’ll also aid to increase the percentage of patients to whom LAI antipsychotics will likely be supplied by psychiatrists as a therapeutic choice. The 6R-Tetrahydro-L-biopterin dihydrochloride cost objective of these recommendations would be to propose a prescription framework to clinicians for the use of a specific formulation of antipsychotics (LAI) in diverse therapeutic indications and distinct clinical situations. The aim will be to let clinicians to supply probably the most proper pharmaceutical techniques to the individuals and to facilitate the usage of LAI antipsychotics in clinical practice. The recommendations presented here from a consensus-based guidelines methodology (Formal Consensus Guidelines) 
arebased on scientific information plus the consensus of a panel of experts.MethodsQuestionnaire developmentInitially, we performed an evaluation in addition to a literature assessment concerning the indications and also the use of LAI antipsychotics. A literature search employing the key phrases “antipsychotic”, “neuroleptic”, “first-generation antipsychotic”, “atypical antipsychotic”, “second-generation antipsychotic”, “long-acting injectable”, “depot”, “depot neuroleptic” was performed in PubMed and EMBASE to locate all the relevant research published. Further references have been identified from http:www.fda.gov and http: www.ema.europa.eu. Information from all of those sources was discussed and an overview of your existing evidence has been graded and summarized making use of the French National Authority for Well being (HAS) “levels of evidence” criteria [16]. Following this initially step, the scientific committee (PML, LS, MA, Computer, SG, SL) created a questionnaire consisting of 32 queries that covered 539 therapeutic choices. The 32 queries were regrouped into three regions PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21310042 that were judged as important: Target-population: Description of the unique indications on the LAI antipsychotics and on the most proper period with the illness to introduce the therapy. Prescription and use: Option in the molecule, methods of introduction, certain methods based on the psychiatric disorder or comorbidities, and therapy monitoring. Distinct population: Use of LAI antipsychotics in pregnant females, elderly sufferers, subjects inside a precarious situation, and subjects obtaining to become treated inside a prison establishment. This questionnaire was made to become completed by an experts’ panel. The time necessary for its administration was estimated at about 3 hours. In the time of improvement, all of the LAI antipsychotics accessible in France have been proposed as therapeutic options (Table 1). They had been regrouped into two categories: Long-acting injectable first-generation antipsychotics (LAI FGA). Long-acting injectable second-generation antipsychotics (LAI SGA). This artificial separation FGASGA isn’t consensual on account of their heterogeneous profiles of efficacyLlorca et al. BMC Psychiatry 2013, 13:340 http:www.biomedcentral.com1471-244X13Page 3 ofTable 1 LAI antipsychotics obtainable in France (when the survey was completed)LAI second-generation antipsychotics LAI first-generation antipsychotics Risperidone microsphere Olanzapine pamoate Haloperidol decanoate Zuclopenthixol decanoate Flupentixol decanoate Fluphenazine decanoate Pipotiazine palmitateNote: as paliperidone palmitate had a promoting authorization date immediately after the improvement of those suggestions, it couldn’t be taken into account.Expert selectionThe Scientific Committee (Appendix 1) sel.