Diffusion of distinct guidelines, addressing each of the aspects on the use of LAI antipsychotics, will increase clinicians’ perceived competence. It’ll also assist to boost the percentage of patients to whom LAI antipsychotics is going to be provided by psychiatrists as a therapeutic alternative. The objective of those recommendations will be to propose a prescription framework to clinicians for the use of a certain formulation of antipsychotics (LAI) in diverse therapeutic indications and certain clinical scenarios. The aim will be to allow clinicians to offer one of the most proper pharmaceutical methods towards the sufferers and to facilitate the use of LAI antipsychotics in clinical practice. The suggestions presented here from a consensus-based guidelines methodology (Formal Consensus Guidelines) arebased on scientific data and also the consensus of a panel of experts.MethodsQuestionnaire developmentInitially, we performed an analysis as well as a literature overview concerning the indications and the use of LAI antipsychotics. A literature search employing the key phrases “antipsychotic”, “neuroleptic”, “first-generation antipsychotic”, “atypical antipsychotic”, “second-generation antipsychotic”, “long-acting injectable”, “depot”, “depot neuroleptic” was performed in PubMed and EMBASE to locate all the relevant research published. Extra references have been identified from http:www.fda.gov and http: www.ema.europa.eu. Information from all of these sources was discussed and an overview from the present evidence has been graded and summarized utilizing the French National Authority for Wellness (HAS) “levels of evidence” criteria [16]. Following this 1st step, the scientific committee (PML, LS, MA, Pc, SG, SL) produced a questionnaire consisting of 32 questions that covered 539 therapeutic options. The 32 queries have been regrouped into 3 places PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21310042 that have been judged as vital: 5-Hydroxypsoralen biological activity Target-population: Description of the distinct indications on the LAI antipsychotics and in the most suitable period from the illness to introduce the therapy. Prescription and use: Selection of your molecule, approaches of introduction, precise tactics according to the psychiatric disorder or comorbidities, and treatment monitoring. Certain population: Use of LAI antipsychotics in pregnant ladies, elderly sufferers, subjects within a precarious situation, and subjects possessing to be treated within a prison establishment. This questionnaire was designed to become completed by an experts’ panel. The time essential for its administration was estimated at around 3 hours. At the time of improvement, all of the LAI antipsychotics offered in France had been proposed as therapeutic selections (Table 1). They had been regrouped into 2 categories: Long-acting injectable first-generation antipsychotics (LAI FGA). Long-acting injectable second-generation antipsychotics (LAI SGA). This artificial separation FGASGA just isn’t consensual due to their heterogeneous profiles of efficacyLlorca 
et al. BMC Psychiatry 2013, 13:340 http:www.biomedcentral.com1471-244X13Page three ofTable 1 LAI antipsychotics accessible in France (when the survey was completed)LAI second-generation antipsychotics LAI first-generation antipsychotics Risperidone microsphere Olanzapine pamoate Haloperidol decanoate Zuclopenthixol decanoate Flupentixol decanoate Fluphenazine decanoate Pipotiazine palmitateNote: as paliperidone palmitate had a marketing and advertising authorization date soon after the improvement of those suggestions, it couldn’t be taken into account.Expert selectionThe Scientific Committee (Appendix 1) sel.