Bolic events.1 As illness progresses toward far more extensiveSee accompanying editorial on page 2812 lung involvement, respiratory failure and acute respiratory distress syndrome are observed inside a minority of individuals.2 A number of reports indicate that thromboembolic events are often diagnosed in individuals with SARS-CoV-Correspondence to: Pietro Minuz, MD, FBPhS, Division of Medicine, University of Verona, Medicina Generale per lo Studio ed il Trattamento della Malattia Ipertensiva, Policlinico GB Rossi Piazzale LA Scuro 10, 37134 Verona, Italy. Email [email protected] These authors contributed equally to this short article. The Data Supplement is obtainable with this article at https://www.ahajournals.org/doi/suppl/10.1161/ATVBAHA.120.315175. For Sources of Funding and Disclosures, see web page 2987. 2020 American Heart Association, Inc. Arterioscler Thromb Vasc Biol is obtainable at www.ahajournals.org/journal/atvbArterioscler Thromb Vasc Biol. 2020;40:2975989. DOI: ten.1161/ATVBAHA.120.DecemberTaus et alPlatelets in COVID-CLINICAL AND POPULATION Research – TNonstandard FGF-3 Proteins web Abbreviations and AcronymsAPTT CB CLEC-2 COVID-19 CT GP IFN IL PMV PRP PSGL-1 PT SARS-CoV-2 TNF- VEGF VWF activated partial thromboplastin time collagen binding C-type lectin receptor two coronavirus EDA2R Proteins Recombinant Proteins disease 2019 computed tomography glycoprotein interferon interleukin platelet-derived microvesicle platelet-rich plasma P-selectin glycoprotein ligand-1 prothrombin time extreme acute respiratory syndrome coronavirus two tumor necrosis factor-alpha vascular endothelial growth element von Willebrand factorHighlightsCirculating platelets in coronavirus illness 2019 (COVID-19) pneumonia demonstrate a certain phenotypic and functional profile which is consistent with that of procoagulant platelets. Platelets in patients with COVID-19 express constitutively P-selectin and kind aggregates with leukocytes, also contributing to inflammation by storing in their granules and releasing cytokines, chemokines, and development elements. Circulating platelets contribute to improved coagulability in COVID-19 patient, which is element XII dependent and tissue factor-factor VII independent.procoagulant and proinflammatory activities.18 The aim of the present investigation was to characterize the phenotypic profile of circulating platelets and define their contribution to a prothrombotic and proinflammatory environment, delivering proof of a close intersection of platelets using the inflammatory procedure.infection. Histology and imaging by angiographic computed tomography (CT) revealed microvascular thrombosis or additional substantial pulmonary thrombosis, usually not linked with peripheral vein thrombosis.three Pulmonary thrombosis may raise the mismatch in between ventilation and perfusion, with serious hypoxemia and precipitating respiratory failure.7 In accordance with CT proof, 25 of COVID-19 patients in medical wards have pulmonary thrombosis, with frequent involvement of segmental and a number of subsegmental pulmonary arteries.4,eight Several observational research described alterations in hemostasis parameters, lowered platelet count, prolonged prothrombin time (PT), and altered activated partial thromboplastin time (APTT) with decreased plasma fibrinogen in later stages from the disease.6,92 On the other hand, the clinical image of disseminated intravascular coagulation is uncommon.13 Hemorrhages, extreme depletion of coagulation components and antithrombin levels, or extreme thrombocytopenia are seldom observed.9 The pulmonary inflamm.