Product Name :
TAS-119
Description:
TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites.
CAS:
1453099-83-6
Molecular Weight:
506.36
Formula:
C23H22Cl2FN5O3
Chemical Name:
1-(2,3-dichlorobenzoyl)-4-({5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl}methyl)piperidine-4-carboxylic acid
Smiles :
CC1=CC(NC2=NC(CC3(CCN(CC3)C(=O)C3=CC=CC(Cl)=C3Cl)C(O)=O)=CC=C2F)=NN1
InChiKey:
PLAVWQHGBMTMFR-UHFFFAOYSA-N
InChi :
InChI=1S/C23H22Cl2FN5O3/c1-13-11-18(30-29-13)28-20-17(26)6-5-14(27-20)12-23(22(33)34)7-9-31(10-8-23)21(32)15-3-2-4-16(24)19(15)25/h2-6,11H,7-10,12H2,1H3,(H,33,34)(H2,27,28,29,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B (IC50 of 95 nM). TAS-119 has potent antitumor activites.|Product information|CAS Number: 1453099-83-6|Molecular Weight: 506.36|Formula: C23H22Cl2FN5O3|Chemical Name: 1-(2,3-dichlorobenzoyl)-4-({5-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl}methyl)piperidine-4-carboxylic acid|Smiles: CC1=CC(NC2=NC(CC3(CCN(CC3)C(=O)C3=CC=CC(Cl)=C3Cl)C(O)=O)=CC=C2F)=NN1|InChiKey: PLAVWQHGBMTMFR-UHFFFAOYSA-N|InChi: InChI=1S/C23H22Cl2FN5O3/c1-13-11-18(30-29-13)28-20-17(26)6-5-14(27-20)12-23(22(33)34)7-9-31(10-8-23)21(32)15-3-2-4-16(24)19(15)25/h2-6,11H,7-10,12H2,1H3,(H,33,34)(H2,27,28,29,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 50 mg/mL (98.74 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bliretrigine} web|{Bliretrigine} Sodium Channel|{Bliretrigine} Protocol|{Bliretrigine} In Vitro|{Bliretrigine} custom synthesis|{Bliretrigine} Epigenetics} |Shelf Life: ≥12 months if stored properly.{{Inclisiran} site|{Inclisiran} Small Interfering RNA (siRNA)|{Inclisiran} Technical Information|{Inclisiran} Data Sheet|{Inclisiran} supplier|{Inclisiran} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24516446 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TAS-119 enhances the antiproliferative effect of Paclitaxel in a variety of human cancer cell lines, including Paclitaxel-resistant cells. TAS-119 (30-300 nM) dose dependently enhances cell growth inhibition by three taxanes (Paclitaxel, Docetaxel, and Cabazitaxel) in HeLa cells. TAS-119 induces mitotic accumulation predominantly in tumor cells, compared with that in normal diploid fibroblasts.|In Vivo:|TAS-119 (5-30 mg/kg; oral administration; twice daily on day 1 and everyday on day 2) treatment induces phosphorylated histone H3 (pHH3) in nude rats with the HeLa-luc xenografts.|Products are for research use only. Not for human use.|