Product Name :
Bongkrekic acid
Description:
Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport.
CAS:
11076-19-0
Molecular Weight:
486.60
Formula:
C28H38O7
Chemical Name:
(2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)-20-(carboxymethyl)-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid
Smiles :
C[C@@H](C/C=C/CC/C=C/C=C\C[C@@H](OC)/C(/C)=C\C=C(/C)\C(O)=O)/C=C/C(/CC(O)=O)=C\C(O)=O
InChiKey:
SHCXABJSXUACKU-WUTQZGRKSA-N
InChi :
InChI=1S/C28H38O7/c1-21(15-18-24(19-26(29)30)20-27(31)32)13-11-9-7-5-6-8-10-12-14-25(35-4)22(2)16-17-23(3)28(33)34/h6,8-12,15-19,21,25H,5,7,13-14,20H2,1-4H3,(H,29,30)(H,31,32)(H,33,34)/b8-6+,11-9+,12-10-,18-15+,22-16-,23-17+,24-19+/t21-,25+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{Moxifloxacin} site|{Moxifloxacin} Bacterial|{Moxifloxacin} Biological Activity|{Moxifloxacin} Data Sheet|{Moxifloxacin} supplier|{Moxifloxacin} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Bromothymol Blue} MedChemExpress|{Bromothymol Blue} {Fluorescent Dye}|{Bromothymol Blue} Purity & Documentation|{Bromothymol Blue} References|{Bromothymol Blue} custom synthesis|{Bromothymol Blue} Cancer}
Additional information:
Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport.|Product information|CAS Number: 11076-19-0|Molecular Weight: 486.60|Formula: C28H38O7|Chemical Name: (2E,4Z,6R,8Z,10E,14E,17S,18E,20Z)-20-(carboxymethyl)-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid|Smiles: C[C@@H](C/C=C/CC/C=C/C=C\C[C@@H](OC)/C(/C)=C\C=C(/C)\C(O)=O)/C=C/C(/CC(O)=O)=C\C(O)=O|InChiKey: SHCXABJSXUACKU-WUTQZGRKSA-N|InChi: InChI=1S/C28H38O7/c1-21(15-18-24(19-26(29)30)20-27(31)32)13-11-9-7-5-6-8-10-12-14-25(35-4)22(2)16-17-23(3)28(33)34/h6,8-12,15-19,21,25H,5,7,13-14,20H2,1-4H3,(H,29,30)(H,31,32)(H,33,34)/b8-6+,11-9+,12-10-,18-15+,22-16-,23-17+,24-19+/t21-,25+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:34337881 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Bongkrekic acid (0-50 μM; 48 hours) stimulated formazan formation in MDA-MB-231, MCF-7 and LTED cells with EC50 of 34.14 μM, >50 μM and 2.58 μM, respectively. Bongkrekic acid (0.1-25 μM; 48 hours) decreases the living cell numbers in LTED cells and parent MCF-7 cells in a dose-dependent manner.|Products are for research use only. Not for human use.|