Product Name :
Afoxolaner
Description:
Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.
CAS:
1093861-60-9
Molecular Weight:
625.87
Formula:
C26H17ClF9N3O3
Chemical Name:
2-[(4-{5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl}naphthalen-1-yl)formamido]-N-(2,2,2-trifluoroethyl)acetamide
Smiles :
O=C(NCC(=O)NCC(F)(F)F)C1=CC=C(C2=CC=CC=C21)C1CC(ON=1)(C1=CC(Cl)=CC(=C1)C(F)(F)F)C(F)(F)F
InChiKey:
OXDDDHGGRFRLEE-UHFFFAOYSA-N
InChi :
InChI=1S/C26H17ClF9N3O3/c27-15-8-13(7-14(9-15)25(31,32)33)23(26(34,35)36)10-20(39-42-23)18-5-6-19(17-4-2-1-3-16(17)18)22(41)37-11-21(40)38-12-24(28,29)30/h1-9H,10-12H2,(H,37,41)(H,38,40)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Duloxetine} MedChemExpress|{Duloxetine} Neuronal Signaling|{Duloxetine} Biological Activity|{Duloxetine} Description|{Duloxetine} custom synthesis|{Duloxetine} Cancer}
Shelf Life:
≥12 months if stored properly.{{Gotistobart} web|{Gotistobart} CTLA-4|{Gotistobart} Purity & Documentation|{Gotistobart} In stock|{Gotistobart} supplier|{Gotistobart} Autophagy}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Afoxolaner is an orally active isoxazoline insecticide/acaricide against Ixodes scapularis in dogs. Afoxolaner acts on the insect γ-aminobutyric acid receptor (GABA) and glutamate receptors, inhibiting GABA & glutamate-regulated uptake of chloride ions, resulting in excess neuronal stimulation and death of the arthropod.|Product information|CAS Number: 1093861-60-9|Molecular Weight: 625.87|Formula: C26H17ClF9N3O3|Chemical Name: 2-[(4-{5-[3-chloro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl}naphthalen-1-yl)formamido]-N-(2,2,2-trifluoroethyl)acetamide|Smiles: O=C(NCC(=O)NCC(F)(F)F)C1=CC=C(C2=CC=CC=C21)C1CC(ON=1)(C1=CC(Cl)=CC(=C1)C(F)(F)F)C(F)(F)F|InChiKey: OXDDDHGGRFRLEE-UHFFFAOYSA-N|InChi: InChI=1S/C26H17ClF9N3O3/c27-15-8-13(7-14(9-15)25(31,32)33)23(26(34,35)36)10-20(39-42-23)18-5-6-19(17-4-2-1-3-16(17)18)22(41)37-11-21(40)38-12-24(28,29)30/h1-9H,10-12H2,(H,37,41)(H,38,40)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 250 mg/mL (399.PMID:24220671 44 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|A single oral treatment with a dose approaching the minimum effective dose of afoxolaner (2.5mg/kg) eliminated the pre-existing infestations of I. scapularis ticks and controlled weekly re-infestations, with efficacy between 98% and 100% recorded until Day 23 and 94% at Day 30.|Products are for research use only. Not for human use.|