Product Name :
SJA710-6
Description:
SJA710-6 is a Hepatic Differentiation Inducer which is able to induce the differentiation of rat MSCs (rMSCs) toward hepatocyte-like cells in vitro, where rMSCs treated with SJA710-6 have typical morphological and functional characteristics of hepatic cells, including glycogen storage, urea secretion, uptake of low density lipoprotein (LDL) and expression of hepatocyte-specific genes and proteins. Expression of FoxH1 (FAST1/2) induces the differentiation of rMSCs towards hepatocyte-like cells, suggesting that this gene plays an important role in the hepatic fate specification of rMSCs.
CAS:
1397255-09-2
Molecular Weight:
439.32
Formula:
C22H20BrFN4
Chemical Name:
2-(4-Bromophenyl)-N-(4-fluorobenzyl)-3-propyl-3H-imidazo[4,5-b]pyridin-5-amine
Smiles :
CCCN1C(=NC2=CC=C(NCC3C=CC(F)=CC=3)N=C12)C1C=CC(Br)=CC=1
InChiKey:
RPNQWWSSADJSGS-UHFFFAOYSA-N
InChi :
InChI=1S/C22H20BrFN4/c1-2-13-28-21(16-5-7-17(23)8-6-16)26-19-11-12-20(27-22(19)28)25-14-15-3-9-18(24)10-4-15/h3-12H,2,13-14H2,1H3,(H,25,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{SKI II} MedChemExpress|{SKI II} Apoptosis|{SKI II} Purity & Documentation|{SKI II} Formula|{SKI II} supplier|{SKI II} Autophagy}
Shelf Life:
≥12 months if stored properly.{{Ecromeximab} MedChemExpress|{Ecromeximab} TGF-beta/Smad|{Ecromeximab} Biological Activity|{Ecromeximab} Formula|{Ecromeximab} supplier}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:36628218
Additional information:
SJA710-6 is a Hepatic Differentiation Inducer which is able to induce the differentiation of rat MSCs (rMSCs) toward hepatocyte-like cells in vitro, where rMSCs treated with SJA710-6 have typical morphological and functional characteristics of hepatic cells, including glycogen storage, urea secretion, uptake of low density lipoprotein (LDL) and expression of hepatocyte-specific genes and proteins. Expression of FoxH1 (FAST1/2) induces the differentiation of rMSCs towards hepatocyte-like cells, suggesting that this gene plays an important role in the hepatic fate specification of rMSCs.|Product information|CAS Number: 1397255-09-2|Molecular Weight: 439.32|Formula: C22H20BrFN4|Synonym:|SJA-710-6|SJA710-6|SJA 710-6|SJA7106|SJA-7106|SJA 7106|Chemical Name: 2-(4-Bromophenyl)-N-(4-fluorobenzyl)-3-propyl-3H-imidazo[4,5-b]pyridin-5-amine|Smiles: CCCN1C(=NC2=CC=C(NCC3C=CC(F)=CC=3)N=C12)C1C=CC(Br)=CC=1|InChiKey: RPNQWWSSADJSGS-UHFFFAOYSA-N|InChi: InChI=1S/C22H20BrFN4/c1-2-13-28-21(16-5-7-17(23)8-6-16)26-19-11-12-20(27-22(19)28)25-14-15-3-9-18(24)10-4-15/h3-12H,2,13-14H2,1H3,(H,25,27)|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Ouyang J, Shao J, Zou H, Lou Y, Yu Y. Hepatic differentiation of rat mesenchymal stem cells by a small molecule. ChemMedChem. 2012 Aug;7(8):1447-52. doi: 10.1002/cmdc.201200162. Epub 2012 Jun 19. PMID: 22715131.Products are for research use only. Not for human use.|