Product Name :
Cirsilineol
Description:
Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice.
CAS:
41365-32-6
Molecular Weight:
344.32
Formula:
C18H16O7
Chemical Name:
5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-4H-chromen-4-one
Smiles :
COC1C(=CC2OC(=CC(=O)C=2C=1O)C1=CC(OC)=C(O)C=C1)OC
InChiKey:
VKOSQMWSWLZQPA-UHFFFAOYSA-N
InChi :
InChI=1S/C18H16O7/c1-22-13-6-9(4-5-10(13)19)12-7-11(20)16-14(25-12)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice.|Product information|CAS Number: 41365-32-6|Molecular Weight: 344.32|Formula: C18H16O7|Chemical Name: 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-6,7-dimethoxy-4H-chromen-4-one|Smiles: COC1C(=CC2OC(=CC(=O)C=2C=1O)C1=CC(OC)=C(O)C=C1)OC|InChiKey: VKOSQMWSWLZQPA-UHFFFAOYSA-N|InChi: InChI=1S/C18H16O7/c1-22-13-6-9(4-5-10(13)19)12-7-11(20)16-14(25-12)8-15(23-2)18(24-3)17(16)21/h4-8,19,21H,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dihydrotachysterol} web|{Dihydrotachysterol} VD/VDR|{Dihydrotachysterol} NF-κB|{Dihydrotachysterol} Protocol|{Dihydrotachysterol} Description|{Dihydrotachysterol} supplier} |Shelf Life: ≥12 months if stored properly.{{Voclosporin} web|{Voclosporin} Molecular Glues|{Voclosporin} Protocol|{Voclosporin} Description|{Voclosporin} manufacturer|{Voclosporin} Autophagy} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:23937941 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Cirsilineol (0.1-10 μM; 96 hours) inhibits single mixed lymphocyte reaction and Concanava A-induced T-cell proliferation in a dose-dependent manner. Cirsilineol (10 μM) does not affect T lymphocyte’s viability. The inhibition of cirsilineol (10 μM) on T-cell proliferation is not due to a cytotoxic activity. Cirsilineol (1-10 μM; pretreatment for 3 hours) completely inhibits IFN-γ-induced Tyr701 phosphorylation of STAT1 and JAK2 activation.|In Vivo:|cirsilineol (3, 10, and 30 mg/kg) significantly ameliorates TNBS-induced Th1-mediated colitis through inhibiting IFN-γ/STAT1/T-bet signaling in CD4+ T cells.|Products are for research use only. Not for human use.|