Product Name :
UMB298
Description:
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor.
CAS:
2266569-73-5
Molecular Weight:
479.01
Formula:
C27H31ClN4O2
Chemical Name:
2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)imidazo[1,2-a]pyridin-3-amine
Smiles :
COC1=CC=C(CCC2N=C3C=C(C=CN3C=2NC2CCCCC2)C2C(C)=NOC=2C)C=C1Cl
InChiKey:
NZXSWCLCRDCHGN-UHFFFAOYSA-N
InChi :
InChI=1S/C27H31ClN4O2/c1-17-26(18(2)34-31-17)20-13-14-32-25(16-20)30-23(27(32)29-21-7-5-4-6-8-21)11-9-19-10-12-24(33-3)22(28)15-19/h10,12-16,21,29H,4-9,11H2,1-3H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
UMB298 is a potent and selective CBP/P300 bromodomain inhibitor.|Product information|CAS Number: 2266569-73-5|Molecular Weight: 479.01|Formula: C27H31ClN4O2|Chemical Name: 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-N-cyclohexyl-7-(3,5-dimethyl-1,2-oxazol-4-yl)imidazo[1,2-a]pyridin-3-amine|Smiles: COC1=CC=C(CCC2N=C3C=C(C=CN3C=2NC2CCCCC2)C2C(C)=NOC=2C)C=C1Cl|InChiKey: NZXSWCLCRDCHGN-UHFFFAOYSA-N|InChi: InChI=1S/C27H31ClN4O2/c1-17-26(18(2)34-31-17)20-13-14-32-25(16-20)30-23(27(32)29-21-7-5-4-6-8-21)11-9-19-10-12-24(33-3)22(28)15-19/h10,12-16,21,29H,4-9,11H2,1-3H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (52.{{Lokivetmab} web|{Lokivetmab} Interleukin Related|{Lokivetmab} Biological Activity|{Lokivetmab} In stock|{Lokivetmab} manufacturer|{Lokivetmab} Cancer} 19 mM; Need ultrasonic).{{Dexamethasone phosphate disodium} site|{Dexamethasone phosphate disodium} Immunology/Inflammation|{Dexamethasone phosphate disodium} Epigenetics|{Dexamethasone phosphate disodium} Protocol|{Dexamethasone phosphate disodium} Formula|{Dexamethasone phosphate disodium} custom synthesis} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:24367939 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|UMB298 (0.01~10 μM; 50 days; MOLM13 and MM cells) inhibits cells growth. UMB298 (1~10 μM; 2 hours; MOLM13 cells) reduces the H3K27ac level similar to CBP30 and causes MYC depletion as a signature of CBP inhibition in acute myeloid leukemia. UMB298 (3 μM; 2hours; MOLM13 cells) down-regulates MYC expression.|Products are for research use only. Not for human use.|