β-Amino acid imagabalin hydrochloride

Description:
β-Amino acid imagabalin hydrochloride is an inhibitor of ion channels. It blocks the voltage-gated sodium and calcium channels, which are responsible for the generation and propagation of action potentials in excitable cells. β-Amino acid imagabalin hydrochloride is a potent blocker of voltage-gated sodium channels with an IC50 of 3 nM in rat dorsal root ganglion neurons. This drug has been shown to inhibit the activity of ligand binding to an antibody or receptor by competing with the natural ligand for binding sites on the antibody or receptor. β-Amino acid imagabalin hydrochloride is also a competitive inhibitor of peptides, such as vasopressin, serotonin, and substance P, that bind to high-affinity receptors.