Product Name :
Salvianolic acid A
Description:
Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.
CAS:
96574-01-5
Molecular Weight:
494.45
Formula:
C26H22O10
Chemical Name:
3-(3,4-dihydroxyphenyl)-2-[(3-{2-[2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl}prop-2-enoyl)oxy]propanoic acid
Smiles :
OC(=O)C(CC1=CC(O)=C(O)C=C1)OC(=O)C=CC1C=CC(O)=C(O)C=1C=CC1=CC(O)=C(O)C=C1
InChiKey:
YMGFTDKNIWPMGF-AGYDPFETSA-N
InChi :
InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation.|Product information|CAS Number: 96574-01-5|Molecular Weight: 494.45|Formula: C26H22O10|Chemical Name: 3-(3,4-dihydroxyphenyl)-2-[(3-{2-[2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl}prop-2-enoyl)oxy]propanoic acid|Smiles: OC(=O)C(CC1=CC(O)=C(O)C=C1)OC(=O)C=CC1C=CC(O)=C(O)C=1C=CC1=CC(O)=C(O)C=C1|InChiKey: YMGFTDKNIWPMGF-AGYDPFETSA-N|InChi: InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.{{Canagliflozin} MedChemExpress|{Canagliflozin} SGLT|{Canagliflozin} Protocol|{Canagliflozin} Formula|{Canagliflozin} manufacturer|{Canagliflozin} Epigenetics} 33 mg/mL (168.{{Protease Inhibitor Cocktail, Bacteria} medchemexpress|{Protease Inhibitor Cocktail, Bacteria} Epigenetics|{Protease Inhibitor Cocktail, Bacteria} Protocol|{Protease Inhibitor Cocktail, Bacteria} References|{Protease Inhibitor Cocktail, Bacteria} supplier} 53 mM; Need ultrasonic).PMID:23907051 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|A significant beneficial effect of Salvianolic acid A (SAA) is observed in the Salvianolic acid A treatment groups. Salvianolic acid A (20 mg/kg) could significantly prolonged the retention time of rats on the plate. While compared with sham operation group, the brain water content in model group significantly increases, which is attenuated significantly by Salvianolic acid A (10 and 20 mg/kg). Compared with the model group, Salvianolic acid A (5, 10, and 20 mg/kg) could maintain the normal structures of neurons and increase neurons number. It is also found that Salvianolic acid A (20 mg/kg) could significantly reduce I/R induced MMP-9 upregulation. While the MMP-2 expression is not significantly affected by Salvianolic acid A. Tissue inhibitors of metalloproteinases (TIMPs) could inhibit the activity of MMPs through high affinity binding to MMPs catalytic domain.|Products are for research use only. Not for human use.|