Meclofenamic acid

Description:
Meclofenamic acid is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the activity of cyclooxygenase and lipoxygenase. It is used for the treatment of mild to moderate pain, dysmenorrhea, and menstrual cramps. Meclofenamic acid binds to polymerase chain reaction (PCR) substrate-binding site, inhibiting DNA synthesis in rat hippocampal neurons. This drug has also been shown to suppress disease activity in animals with experimental arthritis. Meclofenamic acid can be administered orally or intravenously without altering its effect on disease activity or blood sampling results. The drug is rapidly metabolized by hydroxylation and conjugation with glucuronic acid, followed by excretion in urine or feces. Meclofenamic acid significantly cytotoxic to human polymorphonuclear leukocytes at high concentrations, which may be due to its ability to modify RNA synthesis and protein synthesis.