Product Name :
Oleyloxyethyl Phosphorylcholine
Description:
IC50: 6.2 μM for porcine pancreatic PLA2 Oleyloxyethyl phosphorylcholine is a PLA2 inhibitor. Phospholipases A2 (PLA2s) are enzymes releasing fatty acids from glycerol. This particular phospholipase can specifically recognize the sn-2 acyl bond of phospholipids and catalytically hydrolyze the bond releasing arachidonic acid and lysophosphatidic acid. Upon downstream modification by cyclooxygenases, arachidonic acid is modified into active eicosanoids, which are categorized as anti-inflammatory and inflammatory mediators. In vitro: To examine the phospholipids including oleyloxyethyl phosphorylcholine as PLA2 inhibitors, the enzyme assay was employed. Determinations were performed below critical micelle concentration. Porcine pancreatic PLA2 and phospholipid inhibitor were preincubated for 2 min at 37°C in buffer at pH 8.5. Introduction of [l4C]arachidonate phosphatidylcholine initiated the enzymatic reaction, which is quenched after 5 min at 37°C. In this manner 50% inhibitor concentrations were determined for mepacrine and alkylphosphorylcholines, indicating oleyloxyethyl phosphorylcholine was an inhibitor of PLA2 with an IC50 of 6.2 μM for porcine pancreatic PLA2 . In vivo: Up to now, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.
CAS:
84601-19-4
Molecular Weight:
477.66
Formula:
C25H52NO5P
Chemical Name:
2-[(9Z)-octadec-9-en-1-yloxy]ethyl 2-(trimethylazaniumyl)ethyl phosphate
Smiles :
CCCCCCCC/C=C\CCCCCCCCOCCOP([O-])(=O)OCC[N+](C)(C)C
InChiKey:
NPLMVGGTFDUQHL-SEYXRHQNSA-N
InChi :
InChI=1S/C25H52NO5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-29-24-25-31-32(27,28)30-23-21-26(2,3)4/h12-13H,5-11,14-25H2,1-4H3/b13-12-
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Nattokinase} medchemexpress|{Nattokinase} Purity & Documentation|{Nattokinase} In Vitro|{Nattokinase} manufacturer|{Nattokinase} Cancer}
Shelf Life:
≥12 months if stored properly.{{Pevonedistat} medchemexpress|{Pevonedistat} Metabolic Enzyme/Protease|{Pevonedistat} Biological Activity|{Pevonedistat} Purity|{Pevonedistat} supplier|{Pevonedistat} Epigenetic Reader Domain}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:34645436
Additional information:
IC50: 6.2 μM for porcine pancreatic PLA2 Oleyloxyethyl phosphorylcholine is a PLA2 inhibitor. Phospholipases A2 (PLA2s) are enzymes releasing fatty acids from glycerol. This particular phospholipase can specifically recognize the sn-2 acyl bond of phospholipids and catalytically hydrolyze the bond releasing arachidonic acid and lysophosphatidic acid. Upon downstream modification by cyclooxygenases, arachidonic acid is modified into active eicosanoids, which are categorized as anti-inflammatory and inflammatory mediators. In vitro: To examine the phospholipids including oleyloxyethyl phosphorylcholine as PLA2 inhibitors, the enzyme assay was employed. Determinations were performed below critical micelle concentration. Porcine pancreatic PLA2 and phospholipid inhibitor were preincubated for 2 min at 37°C in buffer at pH 8.5. Introduction of [l4C]arachidonate phosphatidylcholine initiated the enzymatic reaction, which is quenched after 5 min at 37°C. In this manner 50% inhibitor concentrations were determined for mepacrine and alkylphosphorylcholines, indicating oleyloxyethyl phosphorylcholine was an inhibitor of PLA2 with an IC50 of 6.2 μM for porcine pancreatic PLA2 . In vivo: Up to now, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.|Product information|CAS Number: 84601-19-4|Molecular Weight: 477.66|Formula: C25H52NO5P|Chemical Name: 2-[(9Z)-octadec-9-en-1-yloxy]ethyl 2-(trimethylazaniumyl)ethyl phosphate|Smiles: CCCCCCCC/C=C\CCCCCCCCOCCOP([O-])(=O)OCC[N+](C)(C)C|InChiKey: NPLMVGGTFDUQHL-SEYXRHQNSA-N|InChi: InChI=1S/C25H52NO5P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-29-24-25-31-32(27,28)30-23-21-26(2,3)4/h12-13H,5-11,14-25H2,1-4H3/b13-12-|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|