Product Name :
NCC007

Description:
NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms.

CAS:
2342583-66-6

Molecular Weight:
447.50

Formula:
C22H28F3N7

Chemical Name:
9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-{[3-(trifluoromethyl)phenyl]methyl}-9H-purine-2, 6-diamine

Smiles :
CN(C)CCNC1=NC(NCC2=CC=CC(=C2)C(F)(F)F)=C2N=CN(C(C)C3CC3)C2=N1

InChiKey:
GHRNSZVMIARHIS-UHFFFAOYSA-N

InChi :
InChI=1S/C22H28F3N7/c1-14(16-7-8-16)32-13-28-18-19(29-21(30-20(18)32)26-9-10-31(2)3)27-12-15-5-4-6-17(11-15)22(23,24)25/h4-6,11,13-14,16H,7-10,12H2,1-3H3,(H2,26,27,29,30)

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥360 days if stored properly.{{Relugolix} web|{Relugolix} GnRH Receptor|{Relugolix} Purity & Documentation|{Relugolix} In Vitro|{Relugolix} supplier|{Relugolix} Cancer}

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
NCC007 is a dual casein kinase Iα (CKIα) and δ (CKIδ) inhibitor with IC50s of 1.8 and 3.6 μM, respectively. NCC007 can be used in research of modulating mammalian circadian rhythms.|Product information|CAS Number: 2342583-66-6|Molecular Weight: 447.50|Formula: C22H28F3N7|Chemical Name: 9-(1-cyclopropylethyl)-N2-[2-(dimethylamino)ethyl]-N6-{[3-(trifluoromethyl)phenyl]methyl}-9H-purine-2, 6-diamine|Smiles: CN(C)CCNC1=NC(NCC2=CC=CC(=C2)C(F)(F)F)=C2N=CN(C(C)C3CC3)C2=N1|InChiKey: GHRNSZVMIARHIS-UHFFFAOYSA-N|InChi: InChI=1S/C22H28F3N7/c1-14(16-7-8-16)32-13-28-18-19(29-21(30-20(18)32)26-9-10-31(2)3)27-12-15-5-4-6-17(11-15)22(23,24)25/h4-6,11,13-14,16H,7-10,12H2,1-3H3,(H2,26,27,29,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (279.{{Perifosine} web|{Perifosine} Akt|{Perifosine} Epigenetics|{Perifosine} Purity & Documentation|{Perifosine} In Vitro|{Perifosine} manufacturer} 33 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33307765 |Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|NCC007 (5-15 mM, infused into the lateral ventricle) controls circadian rhythms through CKI inhibition.|References:|Lee JW, et al. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. J Med Chem. 2019 Feb 28;62(4):1989-1998.Products are for research use only. Not for human use.|

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