Product Name :
TLCK
Sequence:
Na-Tosyl-Lys-chloromethylketone
Purity:
≥95% (HPLC)
Molecular Weight:
369.3
Solubility :
Soluble in methanol (50mg/ml), DMSO (5mM) or water. Stock solutions at concentrations up to 10mM can be prepared in aqueous buffers with a pH of 6.0 or lower. TLCK is very unstable in buffers with a pH higher than 6 and will decompose rapidly.2152628-33-4 Purity
Appearance:
Off-white solid
Use/Stability :
As indicated on product label or CoA when stored as recommended.
Description:
Inhibitor of trypsin and trypsin-like proteases Irreversible inhibitor of trypsin and trypsin-like serine proteases such as granzyme D and tryptase. Also inhibits other proteases including plasmin, thrombin, and papain and some kinases including PKC. Inhibits LPS-induced expression of COX-2 in macrophages.1227961-59-2 Data Sheet Inhibits apoptosis (possibly through the inhibition of serine proteases). Chymotrypsin is not inhibited by TLCK, so this inhibitor can be used to block contaminating trypsin activity in chymoptrypsin preparations. TLCK can be used in combination with a chymotrypsin inhibitor to prevent proteolytic degradation during the isolation of proteins.
CAS :
4238-41-9
Solubility:
Soluble in methanol (50mg/ml), DMSO (5mM) or water.PMID:28520346 Stock solutions at concentrations up to 10mM can be prepared in aqueous buffers with a pH of 6.0 or lower. TLCK is very unstable in buffers with a pH higher than 6 and will decompose rapidly.
Formula:
C14H21CIN2O3S . HCl
Additional Information :
| Alternative Name Nα-Tosyl-Lys-chloromethylketone . HCl | Appearance Off-white solid | CAS 4238-41-9 | Formula C14H21CIN2O3S . HCl | MW 369.3 | Purity ≥95% (HPLC) | Sequence Na-Tosyl-Lys-chloromethylketone | Solubility Soluble in methanol (50mg/ml), DMSO (5mM) or water. Stock solutions at concentrations up to 10mM can be prepared in aqueous buffers with a pH of 6.0 or lower. TLCK is very unstable in buffers with a pH higher than 6 and will decompose rapidly.