Product Name :
m-PEG6-NHS ester
Description:
m-PEG6-NHS ester is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.
CAS:
1449390-12-8
Molecular Weight:
421.44
Formula:
C18H31NO10
Chemical Name:
2,5-dioxopyrrolidin-1-yl 2,5,8,11,14,17-hexaoxaicosan-20-oate
Smiles :
COCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O
InChiKey:
KIIPLYSZOISNAS-UHFFFAOYSA-N
InChi :
InChI=1S/C18H31NO10/c1-23-6-7-25-10-11-27-14-15-28-13-12-26-9-8-24-5-4-18(22)29-19-16(20)2-3-17(19)21/h2-15H2,1H3
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
m-PEG6-NHS ester is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs.|Product information|CAS Number: 1449390-12-8|Molecular Weight: 421.44|Formula: C18H31NO10|Chemical Name: 2,5-dioxopyrrolidin-1-yl 2,5,8,11,14,17-hexaoxaicosan-20-oate|Smiles: COCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O|InChiKey: KIIPLYSZOISNAS-UHFFFAOYSA-N|InChi: InChI=1S/C18H31NO10/c1-23-6-7-25-10-11-27-14-15-28-13-12-26-9-8-24-5-4-18(22)29-19-16(20)2-3-17(19)21/h2-15H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.Ajudecunoid A References |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.VinclozolinM2-2204 In stock |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PMID:33228481 PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.|References:|An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.Products are for research use only. Not for human use.|