Product Name :
β-D-glucuronide-pNP-carbonate
Description:
β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
CAS:
894095-98-8
Molecular Weight:
913.83
Formula:
C45H43N3O18
Chemical Name:
methyl (2S,3S,4S,5R,6S)-3,4,5-tris(acetyloxy)-6-2-[3-([(9H-fluoren-9-yl)methoxy]carbonylamino)propanamido]-4-([(4-nitrophenoxy)carbonyl]oxymethyl)phenoxyoxane-2-carboxylate
Smiles :
COC(=O)[C@H]1O[C@@H](OC2=CC=C(COC(=O)OC3C=CC(=CC=3)[N+]([O-])=O)C=C2NC(=O)CCNC(=O)OCC2C3=CC=CC=C3C3=CC=CC=C32)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O
InChiKey:
DMGQNZOORDYDEZ-LELKPENRSA-N
InChi :
InChI=1S/C45H43N3O18/c1-24(49)61-38-39(62-25(2)50)41(63-26(3)51)43(66-40(38)42(53)58-4)65-36-18-13-27(22-60-45(55)64-29-16-14-28(15-17-29)48(56)57)21-35(36)47-37(52)19-20-46-44(54)59-23-34-32-11-7-5-9-30(32)31-10-6-8-12-33(31)34/h5-18,21,34,38-41,43H,19-20,22-23H2,1-4H3,(H,46,54)(H,47,52)/t38-,39-,40-,41+,43+/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).|Product information|CAS Number: 894095-98-8|Molecular Weight: 913.83|Formula: C45H43N3O18|Chemical Name: methyl (2S,3S,4S,5R,6S)-3,4,5-tris(acetyloxy)-6-2-[3-([(9H-fluoren-9-yl)methoxy]carbonylamino)propanamido]-4-([(4-nitrophenoxy)carbonyl]oxymethyl)phenoxyoxane-2-carboxylate|Smiles: COC(=O)[C@H]1O[C@@H](OC2=CC=C(COC(=O)OC3C=CC(=CC=3)[N+]([O-])=O)C=C2NC(=O)CCNC(=O)OCC2C3=CC=CC=C3C3=CC=CC=C32)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O|InChiKey: DMGQNZOORDYDEZ-LELKPENRSA-N|InChi: InChI=1S/C45H43N3O18/c1-24(49)61-38-39(62-25(2)50)41(63-26(3)51)43(66-40(38)42(53)58-4)65-36-18-13-27(22-60-45(55)64-29-16-14-28(15-17-29)48(56)57)21-35(36)47-37(52)19-20-46-44(54)59-23-34-32-11-7-5-9-30(32)31-10-6-8-12-33(31)34/h5-18,21,34,38-41,43H,19-20,22-23H2,1-4H3,(H,46,54)(H,47,52)/t38-,39-,40-,41+,43+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Doxycycline hyclate Metabolic Enzyme/Protease |Shelf Life: ≥12 months if stored properly.Argireline supplier |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33298664 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.|References:| Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. Products are for research use only. Not for human use.|