Product Name :
β-NF-JQ1
Description:
β-NF-JQ1 is a PROTAC that recruits AhR E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity.
CAS:
2380000-55-3
Molecular Weight:
816.36
Formula:
C45H42ClN5O6S
Chemical Name:
2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0²,⁶]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[2-(2-2-[(4-1-oxo-1H-benzo[f]chromen-3-ylphenyl)methoxy]ethoxyethoxy)ethyl]acetamide
Smiles :
CC1=NN=C2[C@H](CC(=O)NCCOCCOCCOCC3C=CC(=CC=3)C3=CC(=O)C4C5=CC=CC=C5C=CC=4O3)N=C(C3=C(SC(C)=C3C)N12)C1C=CC(Cl)=CC=1
InChiKey:
OZFKLXDOAZGVSV-BHVANESWSA-N
InChi :
InChI=1S/C45H42ClN5O6S/c1-27-28(2)58-45-41(27)43(33-12-15-34(46)16-13-33)48-36(44-50-49-29(3)51(44)45)24-40(53)47-18-19-54-20-21-55-22-23-56-26-30-8-10-32(11-9-30)39-25-37(52)42-35-7-5-4-6-31(35)14-17-38(42)57-39/h4-17,25,36H,18-24,26H2,1-3H3,(H,47,53)/t36-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.1-Methoxycyclopropanecarboxylic acid Mitochondrial Metabolism
Shelf Life:
≥12 months if stored properly.Leniolisib PI3K/Akt/mTOR
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32437567
Additional information:
β-NF-JQ1 is a PROTAC that recruits AhR E3 ligase to target proteins. β-NF-JQ1 is directed against bromodomain-containing (BRD) proteins using β-NF as an AhR ligand, induces the interaction of AhR and BRD proteins, and displays effective anticancer activity that correlated with protein knockdown activity.|Product information|CAS Number: 2380000-55-3|Molecular Weight: 816.36|Formula: C45H42ClN5O6S|Chemical Name: 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0²,⁶]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-[2-(2-2-[(4-1-oxo-1H-benzo[f]chromen-3-ylphenyl)methoxy]ethoxyethoxy)ethyl]acetamide|Smiles: CC1=NN=C2[C@H](CC(=O)NCCOCCOCCOCC3C=CC(=CC=3)C3=CC(=O)C4C5=CC=CC=C5C=CC=4O3)N=C(C3=C(SC(C)=C3C)N12)C1C=CC(Cl)=CC=1|InChiKey: OZFKLXDOAZGVSV-BHVANESWSA-N|InChi: InChI=1S/C45H42ClN5O6S/c1-27-28(2)58-45-41(27)43(33-12-15-34(46)16-13-33)48-36(44-50-49-29(3)51(44)45)24-40(53)47-18-19-54-20-21-55-22-23-56-26-30-8-10-32(11-9-30)39-25-37(52)42-35-7-5-4-6-31(35)14-17-38(42)57-39/h4-17,25,36H,18-24,26H2,1-3H3,(H,47,53)/t36-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|