Product Name :
AMG8380
Description:
AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM.
CAS:
1642112-32-0
Molecular Weight:
543.93
Formula:
C25H16ClF2N3O5S
Chemical Name:
1-3′-chloro-2,5′-difluoro-5-methoxy-[1,1′-biphenyl]-4-yl-N-(1,2-oxazol-3-yl)-2-oxo-1,2-dihydroquinoline-6-sulfonamide
Smiles :
COC1=CC(=C(F)C=C1N1C(=O)C=CC2=CC(=CC=C12)S(=O)(=O)NC1C=CON=1)C1C=C(F)C=C(Cl)C=1
InChiKey:
HXQNEKJQBGXFAG-UHFFFAOYSA-N
InChi :
InChI=1S/C25H16ClF2N3O5S/c1-35-23-12-19(15-8-16(26)11-17(27)9-15)20(28)13-22(23)31-21-4-3-18(10-14(21)2-5-25(31)32)37(33,34)30-24-6-7-36-29-24/h2-13H,1H3,(H,29,30)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Dexrazoxane Protocol
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.Estrone Purity 7 with IC50s of 0.PMID:32310574 907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM.|Product information|CAS Number: 1642112-32-0|Molecular Weight: 543.93|Formula: C25H16ClF2N3O5S|Chemical Name: 1-3′-chloro-2,5′-difluoro-5-methoxy-[1,1′-biphenyl]-4-yl-N-(1,2-oxazol-3-yl)-2-oxo-1,2-dihydroquinoline-6-sulfonamide|Smiles: COC1=CC(=C(F)C=C1N1C(=O)C=CC2=CC(=CC=C12)S(=O)(=O)NC1C=CON=1)C1C=C(F)C=C(Cl)C=1|InChiKey: HXQNEKJQBGXFAG-UHFFFAOYSA-N|InChi: InChI=1S/C25H16ClF2N3O5S/c1-35-23-12-19(15-8-16(26)11-17(27)9-15)20(28)13-22(23)31-21-4-3-18(10-14(21)2-5-25(31)32)37(33,34)30-24-6-7-36-29-24/h2-13H,1H3,(H,29,30)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|