Product Name :
MSG606 TFA
Description:
MSG606 TFA is a potent human MC1 receptor antagonist (IC50=17 nM). MSG606 TFA also partial agonist at human MC3 and MC5 receptors (EC50 values are 59 and 1300 nM, respectively). MSG606 TFA exhibits binding affinity for A375 melanoma cells in vitro. MSG606 TFA reverses morphine-induced hyperalgesia in female mice, with no effect in male mice.
CAS:
Molecular Weight:
1461.53
Formula:
C64H83F3N20O15S
Chemical Name:
(S)-3-((3R, 6R, 9S, 12R, 15S)-15-((1H-imidazol-4-yl)methyl)-6-((1H-indol-3-yl)methyl)-12-benzyl-9-(3-guanidinopropyl)-5, 8, 11, 14, 17, 20-hexaoxo-1-thia-4, 7, 10, 13, 16, 19-hexaazacyclotricosane-3-carboxamido)-4-(((S)-1-(((S)-1-((2-amino-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-4-oxobutanoic acid–2, 2, 2-trifluoroacetic acid (1/1)
Smiles :
NC(=N)NCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CSCCCC(=O)NCC(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@H](CC2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC2=CNC3=CC=CC=C23)C(=O)N1)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)NCC(N)=O.OC(=O)C(F)(F)F
InChiKey:
FNRWRBZUAMZCEI-ZXLAOGNBSA-N
InChi :
InChI=1S/C62H82N20O13S.C2HF3O2/c63-49(83)31-73-53(88)43(24-35-12-3-1-4-13-35)78-54(89)41(18-9-21-69-61(64)65)77-59(94)47(28-52(86)87)81-60(95)48-33-96-23-11-20-50(84)72-32-51(85)75-46(27-38-30-68-34-74-38)58(93)79-44(25-36-14-5-2-6-15-36)56(91)76-42(19-10-22-70-62(66)67)55(90)80-45(57(92)82-48)26-37-29-71-40-17-8-7-16-39(37)40;3-2(4,5)1(6)7/h1-8,12-17,29-30,34,41-48,71H,9-11,18-28,31-33H2,(H2,63,83)(H,68,74)(H,72,84)(H,73,88)(H,75,85)(H,76,91)(H,77,94)(H,78,89)(H,79,93)(H,80,90)(H,81,95)(H,82,92)(H,86,87)(H4,64,65,69)(H4,66,67,70);(H,6,7)/t41-,42-,43-,44+,45+,46-,47-,48-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MSG606 TFA is a potent human MC1 receptor antagonist (IC50=17 nM). MSG606 TFA also partial agonist at human MC3 and MC5 receptors (EC50 values are 59 and 1300 nM, respectively). MSG606 TFA exhibits binding affinity for A375 melanoma cells in vitro. MSG606 TFA reverses morphine-induced hyperalgesia in female mice, with no effect in male mice.|Product information|Molecular Weight: 1461.53|Formula: C64H83F3N20O15S|Chemical Name: (S)-3-((3R, 6R, 9S, 12R, 15S)-15-((1H-imidazol-4-yl)methyl)-6-((1H-indol-3-yl)methyl)-12-benzyl-9-(3-guanidinopropyl)-5, 8, 11, 14, 17, 20-hexaoxo-1-thia-4, 7, 10, 13, 16, 19-hexaazacyclotricosane-3-carboxamido)-4-(((S)-1-(((S)-1-((2-amino-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-4-oxobutanoic acid–2, 2, 2-trifluoroacetic acid (1/1)|Smiles: NC(=N)NCCC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]1CSCCCC(=O)NCC(=O)N[C@@H](CC2=CNC=N2)C(=O)N[C@H](CC2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](CC2=CNC3=CC=CC=C23)C(=O)N1)C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)NCC(N)=O.N-Desmethylclozapine custom synthesis OC(=O)C(F)(F)F|InChiKey: FNRWRBZUAMZCEI-ZXLAOGNBSA-N|InChi: InChI=1S/C62H82N20O13S.Argireline In Vivo C2HF3O2/c63-49(83)31-73-53(88)43(24-35-12-3-1-4-13-35)78-54(89)41(18-9-21-69-61(64)65)77-59(94)47(28-52(86)87)81-60(95)48-33-96-23-11-20-50(84)72-32-51(85)75-46(27-38-30-68-34-74-38)58(93)79-44(25-36-14-5-2-6-15-36)56(91)76-42(19-10-22-70-62(66)67)55(90)80-45(57(92)82-48)26-37-29-71-40-17-8-7-16-39(37)40;3-2(4,5)1(6)7/h1-8,12-17,29-30,34,41-48,71H,9-11,18-28,31-33H2,(H2,63,83)(H,68,74)(H,72,84)(H,73,88)(H,75,85)(H,76,91)(H,77,94)(H,78,89)(H,79,93)(H,80,90)(H,81,95)(H,82,92)(H,86,87)(H4,64,65,69)(H4,66,67,70);(H,6,7)/t41-,42-,43-,44+,45+,46-,47-,48-;/m0.PMID:32791892 /s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|