Product Name :
ZN-c3
Description:
ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer.
CAS:
2376146-48-2
Molecular Weight:
526.63
Formula:
C29H34N8O2
Chemical Name:
(R)-2-allyl-1-(7-ethyl-7-hydroxy-6, 7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1, 2-dihydro-3H-pyrazolo[3, 4-d]pyrimidin-3-one
Smiles :
CN1CCN(CC1)C1C=CC(=CC=1)NC1=NC2=C(C=N1)C(=O)N(CC=C)N2C1=CC=C2CC[C@](O)(CC)C2=N1
InChiKey:
OXTSYWDBUVRXFF-GDLZYMKVSA-N
InChi :
InChI=1S/C29H34N8O2/c1-4-14-36-27(38)23-19-30-28(31-21-7-9-22(10-8-21)35-17-15-34(3)16-18-35)33-26(23)37(36)24-11-6-20-12-13-29(39,5-2)25(20)32-24/h4,6-11,19,39H,1,5,12-18H2,2-3H3,(H,30,31,33)/t29-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer.|Product information|CAS Number: 2376146-48-2|Molecular Weight: 526.63|Formula: C29H34N8O2|Chemical Name: (R)-2-allyl-1-(7-ethyl-7-hydroxy-6, 7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1, 2-dihydro-3H-pyrazolo[3, 4-d]pyrimidin-3-one|Smiles: CN1CCN(CC1)C1C=CC(=CC=1)NC1=NC2=C(C=N1)C(=O)N(CC=C)N2C1=CC=C2CC[C@](O)(CC)C2=N1|InChiKey: OXTSYWDBUVRXFF-GDLZYMKVSA-N|InChi: InChI=1S/C29H34N8O2/c1-4-14-36-27(38)23-19-30-28(31-21-7-9-22(10-8-21)35-17-15-34(3)16-18-35)33-26(23)37(36)24-11-6-20-12-13-29(39,5-2)25(20)32-24/h4,6-11,19,39H,1,5,12-18H2,2-3H3,(H,30,31,33)/t29-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Mepolizumab (anti-IL5) Interleukin Related |Shelf Life: ≥12 months if stored properly.Valacyclovir Protocol |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32744117 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ZN-c3 IC50 is 103 nM in H23c cells.|In Vivo:|ZN-c3 (80 mg/kg; p.o.; 28 days) can effectively shrank tumors at 80 mg/kg as a single agent. ZN-c3 shows excellent exposures and bioavailability in the dog PK study.|Products are for research use only. Not for human use.|