Product Name :
TLR7/8 agonist 1 dihydrochloride
Description:
TLR7/8 agonist 1 dihydrochloride is a toll-like receptor TLR7/TLR8 dual-agonistic imidazoquinoline.
CAS:
1620278-72-9
Molecular Weight:
432.39
Formula:
C22H27Cl2N5
Chemical Name:
1-[4-(aminomethyl)phenyl]methyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride
Smiles :
Cl.Cl.CCCCC1=NC2=C(C3=CC=CC=C3N=C2N)N1CC1=CC=C(CN)C=C1
InChiKey:
YKZCFKIAMHQQAW-UHFFFAOYSA-N
InChi :
InChI=1S/C22H25N5.2ClH/c1-2-3-8-19-26-20-21(17-6-4-5-7-18(17)25-22(20)24)27(19)14-16-11-9-15(13-23)10-12-16;;/h4-7,9-12H,2-3,8,13-14,23H2,1H3,(H2,24,25);2*1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Eltanexor Technical Information
Additional information:
TLR7/8 agonist 1 dihydrochloride is a toll-like receptor TLR7/TLR8 dual-agonistic imidazoquinoline.Amikacin Protocol |Product information|CAS Number: 1620278-72-9|Molecular Weight: 432.39|Formula: C22H27Cl2N5|Chemical Name: 1-[4-(aminomethyl)phenyl]methyl-2-butyl-1H-imidazo[4,5-c]quinolin-4-amine dihydrochloride|Smiles: Cl.Cl.CCCCC1=NC2=C(C3=CC=CC=C3N=C2N)N1CC1=CC=C(CN)C=C1|InChiKey: YKZCFKIAMHQQAW-UHFFFAOYSA-N|InChi: InChI=1S/C22H25N5.2ClH/c1-2-3-8-19-26-20-21(17-6-4-5-7-18(17)25-22(20)24)27(19)14-16-11-9-15(13-23)10-12-16;;/h4-7,9-12H,2-3,8,13-14,23H2,1H3,(H2,24,25);2*1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 83.33 mg/mL (192.72 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:32459605 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity. TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC50 of 20 nM. TLR7/8 agonist 1 (Compound 1) shows substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens.|Products are for research use only. Not for human use.|