Product Name :
Rabbit anti-MBTPS2 Polyclonal Antibody(N-term)
Synonym :
Membrane-bound transcription factor site-2 protease; Endopeptidase S2P; Sterol regulatory element-binding proteins intramembrane protease; SREBPs intramembrane protease; MBTPS2; S2P
Host :
Rabbit
Species Reactivity:
Human
Specificity :
This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human MBTPS2.
Predicted Reactivity:
Bovine, Mouse
Applications :
WB~~1:1000IHC-P~~1:10~50
Immunogen:
Concentration :
Purification :
Clonality:
Polyclonal Antibody
Storage Temp.:
Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles
Research areas :
Metabolism Antibodies;Cardiovascular;Cell Biology;Signal Transduction;Others
Background :
Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.
UniProt :
O43462
Additional information:
Product Details FAQ Citations(0) Video Pictures Documents |Overview |Synonym Membrane-bound transcription factor site-2 protease; Endopeptidase S2P; Sterol regulatory element-binding proteins intramembrane protease; SREBPs intramembrane protease; MBTPS2; S2P |Host Rabbit |Specificity This MBTPS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-44 amino acids from the N-terminal region of human MBTPS2. |Species Reactivity Human |Predicted Reactivity Bovine, Mouse |Applications WB~~1:1000IHC-P~~1:10~50 |Properties |Clonality Polyclonal Antibody |Isotype Rabbit Ig |Storage Temp. Maintain refrigerated at 2-8 ° C for up to 2 weeksFor long term storage store at -20 ° C in small aliquots to prevent free that cycles |Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |Research areas Metabolism Antibodies;Cardiovascular;Cell Biology;Signal Transduction;Others |Target |Background Intramembrane proteolysis of sterol-regulatory element- binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop. |Cellular localization Membrane; Multi-pass membrane protein Cytoplasm |UniProt O43462 |References |References Ming, A., et al. Pediatr Dermatol 26(4):427-431(2009)Oeffner, F., et al. Am. J. Hum. Genet. 84(4):459-467(2009)Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)Shen, J., et al. J. Biol. Chem. 279(41):43046-43051(2004)Lee, K., et al. Genes Dev. 16(4):452-466(2002) |Tips:This product is for research use only. Not for use in diagnostic prodcedures.
Rabbit anti-MBTPS2 Polyclonal Antibody(N-term)
Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.Related websites: https://www.medchemexpress.com/antibodies.html
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