Product Name :
Complement factor D-IN-1
Description:
Complement factor D-IN-1 is a potent and selective small-molecule reversible factor d inhibitor, with IC50s of 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively.
CAS:
1386455-76-0
Molecular Weight:
483.32
Formula:
C21H19BrN6O3
Chemical Name:
1-{2-[(1R,3S,5R)-3-[(6-bromopyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxoethyl}-1H-indazole-3-carboxamide
Smiles :
NC(=O)C1=NN(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2=CC=CC(Br)=N2)C2=CC=CC=C12
InChiKey:
CWZUTHDJLNZLCM-DFBGVHRSSA-N
InChi :
InChI=1S/C21H19BrN6O3/c22-16-6-3-7-17(24-16)25-21(31)15-9-11-8-14(11)28(15)18(29)10-27-13-5-2-1-4-12(13)19(26-27)20(23)30/h1-7,11,14-15H,8-10H2,(H2,23,30)(H,24,25,31)/t11-,14-,15+/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Rosuvastatin} site|{Rosuvastatin} Metabolic Enzyme/Protease|{Rosuvastatin} Biological Activity|{Rosuvastatin} In Vivo|{Rosuvastatin} custom synthesis|{Rosuvastatin} Epigenetic Reader Domain}
Additional information:
Complement factor D-IN-1 is a potent and selective small-molecule reversible factor d inhibitor, with IC50s of 0.006 and 0.05 μM in FD Thioesterolytic Fluorescent Assay and a MAC Deposition Assay, respectively.|Product information|CAS Number: 1386455-76-0|Molecular Weight: 483.32|Formula: C21H19BrN6O3|Chemical Name: 1-{2-[(1R,3S,5R)-3-[(6-bromopyridin-2-yl)carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxoethyl}-1H-indazole-3-carboxamide|Smiles: NC(=O)C1=NN(CC(=O)N2[C@@H]3C[C@@H]3C[C@H]2C(=O)NC2=CC=CC(Br)=N2)C2=CC=CC=C12|InChiKey: CWZUTHDJLNZLCM-DFBGVHRSSA-N|InChi: InChI=1S/C21H19BrN6O3/c22-16-6-3-7-17(24-16)25-21(31)15-9-11-8-14(11)28(15)18(29)10-27-13-5-2-1-4-12(13)19(26-27)20(23)30/h1-7,11,14-15H,8-10H2,(H2,23,30)(H,24,25,31)/t11-,14-,15+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (517.26 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|The highly specific S1 serine protease factor D (FD) plays a central role in the amplification of the complement alternative pathway (AP) of the innate immune system.{{AD80} web|{AD80} Raf|{AD80} Protocol|{AD80} In Vitro|{AD80} manufacturer|{AD80} Epigenetic Reader Domain} Complement factor D-IN-1 (compound 2) shows similar potency against human and monkey FD (IC50s in FD thioesterolytic assays of 0.PMID:24140575 005 μM and in 50% serum MAC deposition assays of 0.011 μM for both human and monkey).|In Vivo:|Complement factor D-IN-1 displays an excellent oral PK profile in Sprague–Dawley rats and, following an oral dose (10 mg/kg) in Brown Norway rats, demonstrates a good distribution and sustained exposure in ocular tissues including the neural retina and the posterior eye cup (PEC), which comprises the sclera, retinal pigmented epithelium, and choroid. Mean exposure levels in plasma, the PEC, and the retina at 6 h after dosing are 0.36, 0.43, and 0.09 μM, respectively.|Products are for research use only. Not for human use.|