Product Name :
BMS-986318
Description:
BMS-986318 is a potent nonbile acid FXR agonist with EC50s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis.
CAS:
2314378-09-9
Molecular Weight:
615.43
Formula:
C30H23Cl2F3N4O3
Chemical Name:
Smiles :
OC(=O)C1=CC(=C2C=C(C=CC2=N1)N1CCC2(CC(=C2)C2C(=NOC=2C2CC2)C2=C(Cl)C=NC=C2Cl)CC1)C(F)(F)F
InChiKey:
WPGAVSDZYIRUGE-UHFFFAOYSA-N
InChi :
InChI=1S/C30H23Cl2F3N4O3/c31-20-13-36-14-21(32)25(20)26-24(27(42-38-26)15-1-2-15)16-11-29(12-16)5-7-39(8-6-29)17-3-4-22-18(9-17)19(30(33,34)35)10-23(37-22)28(40)41/h3-4,9-11,13-15H,1-2,5-8,12H2,(H,40,41)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
BMS-986318 is a potent nonbile acid FXR agonist with EC50s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis.|Product information|CAS Number: 2314378-09-9|Molecular Weight: 615.43|Formula: C30H23Cl2F3N4O3|Smiles: OC(=O)C1=CC(=C2C=C(C=CC2=N1)N1CCC2(CC(=C2)C2C(=NOC=2C2CC2)C2=C(Cl)C=NC=C2Cl)CC1)C(F)(F)F|InChiKey: WPGAVSDZYIRUGE-UHFFFAOYSA-N|InChi: InChI=1S/C30H23Cl2F3N4O3/c31-20-13-36-14-21(32)25(20)26-24(27(42-38-26)15-1-2-15)16-11-29(12-16)5-7-39(8-6-29)17-3-4-22-18(9-17)19(30(33,34)35)10-23(37-22)28(40)41/h3-4,9-11,13-15H,1-2,5-8,12H2,(H,40,41)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Capmatinib} web|{Capmatinib} Protein Tyrosine Kinase/RTK|{Capmatinib} Purity & Documentation|{Capmatinib} In stock|{Capmatinib} manufacturer|{Capmatinib} Autophagy} |Shelf Life: ≥12 months if stored properly.{{Capreomycin} MedChemExpress|{Capreomycin} Anti-infection|{Capreomycin} Protocol|{Capreomycin} In stock|{Capreomycin} custom synthesis|{Capreomycin} Epigenetic Reader Domain} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24423657 |Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|