Product Name :
AG-221 (Enasidenib), IHD2 Inhibitor
Description:
Enasidenib, also known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). The mutations of IDH2 present in certain cancer cells result in a new ability of the enzyme to catalyze the NAPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). The production of 2HG is believed to contribute to the formation and progression of cancer . The inhibition of mutant IDH2 and its neoactivity is therefore a potential therapeutic treatment for cancer.
CAS:
1446502-11-9
Molecular Weight:
473.38
Formula:
C19H17F6N7O
Chemical Name:
2-methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol
Smiles :
CC(C)(O)CNC1N=C(NC2C=C(N=CC=2)C(F)(F)F)N=C(N=1)C1=CC=CC(=N1)C(F)(F)F
InChiKey:
DYLUUSLLRIQKOE-UHFFFAOYSA-N
InChi :
InChI=1S/C19H17F6N7O/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Enasidenib, also known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). The mutations of IDH2 present in certain cancer cells result in a new ability of the enzyme to catalyze the NAPH-dependent reduction of α-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). The production of 2HG is believed to contribute to the formation and progression of cancer . The inhibition of mutant IDH2 and its neoactivity is therefore a potential therapeutic treatment for cancer.|Product information|CAS Number: 1446502-11-9|Molecular Weight: 473.38|Formula: C19H17F6N7O|Chemical Name: 2-methyl-1-((4-(6-(trifluoromethyl)pyridin-2-yl)-6-((2-(trifluoromethyl)pyridin-4-yl)amino)-1,3,5-triazin-2-yl)amino)propan-2-ol|Smiles: CC(C)(O)CNC1N=C(NC2C=C(N=CC=2)C(F)(F)F)N=C(N=1)C1=CC=CC(=N1)C(F)(F)F|InChiKey: DYLUUSLLRIQKOE-UHFFFAOYSA-N|InChi: InChI=1S/C19H17F6N7O/c1-17(2,33)9-27-15-30-14(11-4-3-5-12(29-11)18(20,21)22)31-16(32-15)28-10-6-7-26-13(8-10)19(23,24)25/h3-8,33H,9H2,1-2H3,(H2,26,27,28,30,31,32)|Technical Data|Appearance: Solid Power.{{Tegoprazan} web|{Tegoprazan} Proton Pump|{Tegoprazan} Purity & Documentation|{Tegoprazan} Description|{Tegoprazan} manufacturer|{Tegoprazan} Epigenetic Reader Domain} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 50 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{D-Galactose} site|{D-Galactose} Endogenous Metabolite|{D-Galactose} Purity & Documentation|{D-Galactose} In Vivo|{D-Galactose} manufacturer|{D-Galactose} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:23381626 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|AG-221 was used at 1 µM in vitro and cellular assays.|In Vivo:|AG-221 was dosed orally to mice bearing IDH2 mutant tumors at 5-50 mg/Kg once per day.|References:|Chong-Hui Gu, et al. Crystalline forms of therapeutically active compounds and use thereof. (2015) PCT WO 2015018060Products are for research use only. Not for human use.|Documents||