Product Name :
Dazoxiben HCl
Description:
Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots.
CAS:
74226-22-5
Molecular Weight:
268.70
Formula:
C12H13ClN2O3
Chemical Name:
4-(2-(1H-Imidazol-1-yl)ethoxy)benzoic acid hydrochloride
Smiles :
Cl.OC(=O)C1C=CC(=CC=1)OCCN1C=NC=C1
InChiKey:
PVKDFUXBDJPRGU-UHFFFAOYSA-N
InChi :
InChI=1S/C12H12N2O3.ClH/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14;/h1-6,9H,7-8H2,(H,15,16);1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Atrasentan} web|{Atrasentan} Endothelin Receptor|{Atrasentan} Technical Information|{Atrasentan} Description|{Atrasentan} custom synthesis|{Atrasentan} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots.|Product information|CAS Number: 74226-22-5|Molecular Weight: 268.{{Candesartan} medchemexpress|{Candesartan} Cell Cycle/DNA Damage|{Candesartan} Technical Information|{Candesartan} Data Sheet|{Candesartan} supplier|{Candesartan} Autophagy} 70|Formula: C12H13ClN2O3|Chemical Name: 4-(2-(1H-Imidazol-1-yl)ethoxy)benzoic acid hydrochloride|Smiles: Cl.PMID:23460641 OC(=O)C1C=CC(=CC=1)OCCN1C=NC=C1|InChiKey: PVKDFUXBDJPRGU-UHFFFAOYSA-N|InChi: InChI=1S/C12H12N2O3.ClH/c15-12(16)10-1-3-11(4-2-10)17-8-7-14-6-5-13-9-14;/h1-6,9H,7-8H2,(H,15,16);1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 62.5 mg/mL (232.60 mM; Need ultrasonic)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Dazoxiben inhibits TXB2 production in clotting human whole blood with an IC50 of 0.3 μM and causes parallel enhancement of PGE2 greater than PGF2 alpha greater than 6-keto-PGF1 alpha production. Dazoxiben inhibits TXB2 production in rat kidney glomeruli with an IC50 of 1.60 μM) than in rat whole blood (IC50= 0.32μM), and is not associated with changes in PGE2, PGF2 alpha and 6-keto-PGF1 alpha production.|In Vivo:|Dazoxiben (intraperitoneal administration; 100 μg/kg) produces a marked prolongation of the tail bleeding time with 96.8 ± 10.8 secs.|References:|Patrignani P, et al. Differential effects of dazoxiben, a selective thromboxane-synthase inhibitor, on platelet and renal prostaglandin-endoperoxide metabolism.J Pharmacol Exp Ther. 1984 Feb;228(2):472-7.Yu SM, et al. Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor.Br J Pharmacol. 1994 Mar;111(3):906-12.Products are for research use only. Not for human use.|