Product Name :
ML240
Description:
ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM.
CAS:
1346527-98-7
Molecular Weight:
396.44
Formula:
C23H20N6O
Chemical Name:
2-(2-amino-1H-1,3-benzodiazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine
Smiles :
COC1C=CC=C2C(NCC3C=CC=CC=3)=NC(=NC=12)N1C(N)=NC2C=CC=CC1=2
InChiKey:
NHAMBLRUUJAFOY-UHFFFAOYSA-N
InChi :
InChI=1S/C23H20N6O/c1-30-19-13-7-10-16-20(19)27-23(28-21(16)25-14-15-8-3-2-4-9-15)29-18-12-6-5-11-17(18)26-22(29)24/h2-13H,14H2,1H3,(H2,24,26)(H,25,27,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dazodalibep} web|{Dazodalibep} Biological Activity|{Dazodalibep} Purity|{Dazodalibep} manufacturer|{Dazodalibep} Autophagy}
Shelf Life:
≥12 months if stored properly.{{DNQX} MedChemExpress|{DNQX} Neuronal Signaling|{DNQX} Epigenetics|{DNQX} Biological Activity|{DNQX} In stock|{DNQX} supplier}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:24118276
Additional information:
ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC50 value of 100 nM.|Product information|CAS Number: 1346527-98-7|Molecular Weight: 396.44|Formula: C23H20N6O|Chemical Name: 2-(2-amino-1H-1,3-benzodiazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine|Smiles: COC1C=CC=C2C(NCC3C=CC=CC=3)=NC(=NC=12)N1C(N)=NC2C=CC=CC1=2|InChiKey: NHAMBLRUUJAFOY-UHFFFAOYSA-N|InChi: InChI=1S/C23H20N6O/c1-30-19-13-7-10-16-20(19)27-23(28-21(16)25-14-15-8-3-2-4-9-15)29-18-12-6-5-11-17(18)26-22(29)24/h2-13H,14H2,1H3,(H2,24,26)(H,25,27,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (63.06 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|ML240 is a potent p97 inhibitor, with an IC50 of 100 nM. ML240 is active in the UbG76V-GFP stabilization assay (IC50, 0.9 μM). ML240 inhibits p97 competitively with respect to ATP with a Ki values of 0.22 μM. ML240 also inhibits labeling of only three protein kinase domains by >50% when tested at 20 μM: PIP5 K3 (belongs to phosphoinositide-3 kinase family), JAK1 JH2 (N-terminal pseudokinase domain of JAK1), and DNAPK (DNA-dependent protein kinase). ML240 (1.1, 3.3, 10, or 20 μM) induces executioner caspases 3 and 7 and triggers cell death independently of apical caspases 8 and 9. ML240 is cytotoxic to HCT15 and SW403 cells, with GI50s of 0.76 and 0.5 μM after treatment for 24 h, and 0.54 and 0.5 μM after treatment for 72 h, respectively.|Products are for research use only. Not for human use.|