These residues (daring) are within a conserved [KR]x[KRN][NSTP][PLIV][VFI][CIV]xF[AVI][STV]P[LIV] motif that is found directly downstream of MCRIII (underlined)
Accordingly, the a-helix spanning ChREBP sites 116?35 is important for fourteen-three-3 binding as is R128A , suggesting the invariant RLNN and WR residITE customer reviewsues are involved in 14-three-3 interactions.…